Harischandran, S., Shankar, I. R., Raju, R., Shibi, A., Sayana, P. S.
A simple, rapid and economic stability indicating high performance liquid chromatography method was developed for the determination of Silodosin in pharmaceutical dosage form. The chromatographic system comprised of a reverse phase Phenomenex C 18, 5µ Silica (250×4mm) column maintained at 25°C with mobile phase consisting of a mixture of methanol-water-acetonitrile-glacial acetic acid (60:27:10:3 % v/v) at pH 3.2 ± 0.1 with a flow rate of 1 ml/min, determined at 270 nm. The method was linear in the range of 10-100µg/ml. The results were validated according to ICH guidelines. The method could effectively separate the drug from its degradation products.
Silodosin, HPLC, Stability indicating, Validation, degradation
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Harischandran, S., Shankar, I. R., Raju, R., Shibi, A., & Sayana, P. S. (2012). Validated Stability Indicating RP-HPLC Method for the Determination of Silodosin in Pharmaceutical Dosage Form. International Journal for Pharmaceutical Research Scholars (IJPRS), 1(4), 141-145.