Cerebral ischemia (stroke) is one of the foremost causes of high morbidity and mortality for both developed and developing countries. Cerebral ischemia impairs the normal neurological functions which are triggered by a complex series of biochemical and molecular mechanism. Studies in experimental ischemia models have contributed vastly in understanding the pathophysiology of stroke. Moreover animal models provide a testing ground for novel compounds before their launching into any clinical trials. Animal models of tissue injury in stroke are designed to generate reproducible infarcts in a high throughput manner with a minimum of surgical manipulation to determine mechanisms of cell death and to test novel drugs as recanalyzing, neuroprotective, neuroregenerative and anti- inflammatory therapies. It has been years since tissue-type plasminogen activator (t-PA) became the first medication approved by the FDA for the management of stroke, with limited success. Thrombolytic therapy is the most effective therapeutic strategy for the prevention of brain injury and reduction of mortality in patients with cerebral infarction. However, a combination of established thrombolytic therapy and effective neuronal protection therapy may have more beneficial effects for patients with cerebral infarction. Because clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned towards approaches which include herbal drugs that can be used in limiting the neurological damage associated with stroke. This paper commonly reviews the number of herbal medicinal plants effective for the treatment of stroke.
Cerebral Stroke, Pathophysiology, Neuroprotective, Tissue Injury, Herbal Drugs
Cite This Article
Tripathi, D. (2016). A Review on Use of Some Herbal Medicinal Plants in Treatment of Cerebral Stroke, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(4), 128-134.