Faheemuddin, M.D., Ahmed, A., Kumar, S., Shirisha.
To evaluate the anti-diabetic activity of the Plant leaves of Polygonum glabrum in alloxan induced diabetic rats. Method: Diabetes was induced in Wistar rats using freshly prepared solution of Alloxan monohydrate (100 mg/kg b. wt.) by Intraperitoneal route of drug administration. Methanolic extract of Polygonum glabrum (200, 400 mg/kg bwt/p.o) was prepared freshly, administered to alloxan induced diabetic rats for 28 days. The standard drug glibenclamide (10 mg/kg of b. wt) orally. Blood glucose levels was estimated on 0, 7th, 14th, 21st and 28th days, serum glucose level, lipid profile, and histopathological changes in pancreas were examined after 28 days. OGTT was performed by administration of 200 and 400 mg/kg b.w/p.o of methanolic extract of Polygonum glabrum and 10 mg/kg b.w /p.o of Glibenclamide to different groups respectively in normal rats. Results: significant(p<0.001) results were observed in the estimated parameters like reduction in blood glucose , Improved in regeneration of beta cells of langerhans of pancreas in rats by histopathological studies. Conclusion: The results were suggested that the whole plant extract of Polygonum glabrum having potent antidiabetic activity on alloxan induced diabetic rats.
Anti-diabetic, Polygonum glabrum, alloxan induced diabetic rats, OGTT, Glibenclamide
Cite This Article
Faheemuddin, M.D., Ahmed, A., Kumar, S., & Shirisha. (2016). Antidiabetic Activity of Methanolic Extract of Polygonum glabrum Wild Leaves in Diabetic Rats, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(1), 172-179.