Design, Synthesis and Biological Evaluation of Some Novel Substituted Thiazolidinone Derivatives as Potent Antihyperglycemic Agents

Author(s)

Ahmed, O., Salahuddin, M. D., Vinutha, K., Sharma, P.

Author's Affiliation

Abstract

The main obejcetive of this study is to synthesize 2-(substituted phenyl)-3-[{4-(1-naphthyl)-1, 3-thiazol-2-yl} amino]-5-methyl-1, 3-thiazolidin-4-ones (TM₁-TM₁₀) from 1-acetyl naphthalene. The synthesized compound, characterized on the basis of satisfactory analytical and spectral (IR, H¹NMR, Mass) data, have shown moderate to good antidiabetic activity.

Keywords

Antihyperglycemic activity, 1-Acetylnaphthalene, Thiazoles, Thiazolidinones

Cite This Article

Ahmed, O., Salahuddin, M. D., Vinutha, K., & Sharma, P. (2013). Design, Synthesis and Biological Evaluation of Some Novel Substituted Thiazolidinone Derivatives as Potent Antihyperglycemic Agents. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(3), 166-173.