Development and Evaluation of Gastro-Retentive Floating Acyclovir Tablets

Author(s)

Girani, S., Zafar, S., Kavatekar, M., Shahapur, A., Vijapure, V.

Author's Affiliation

Abstract

In the present study an attempt was made to prepare acyclovir floating tablets. Acyclovir floating tablets (200mg) were prepared by direct compression method using HPMC, sodium carboxy methyl cellulose and carbopol with an effervescent base (sod. Bicarbonate and citric acid). FTIR study confirmed the absence of any drug/polymer/excipients interactions. The prepared floating tablets were evaluated for hardness, weight variation, thickness, friability, drug content uniformity, buoyancy lag time, total floating time, swelling index and in vitro dissolution studies. Among all the 12 formulations F1, F2, F3, F4, F5, F6, F10, F11, F12 showed good floating property while formulations F7, F8, F9 showed moderate floating while all the 12 formulations showed controlled drug release. Stability studies were carried out for F4 and F10, both the formulations showed good stability. It was observed that F4 and F10 gave maximum drug release upto 97.17% within 24 hrs.SEM  study indicates that both the tablets F4 &F10 have smooth and uniform surface before the dissolution study, but after the dissolution study, the Tablet F4  which was prepared withsod.CMC has shown erosion of the polymer matrix. But the Tablet F10 have shown spongy like structure, the matrix was swollen and pores were created.

Keywords

Gastro-retentive, Acyclovir, Swelling Index, Gas Generating Agent

Cite This Article

Girani, S., Zafar, S., Kavatekar, M., Shahapur, A., & Vijapure, V. (2015). Development and Evaluation of Gastro-Retentive Floating Acyclovir Tablets, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(4), 104-114.