Formulation and Evaluation of Extended Release Tablets of Diltiazem HCl

Author(s)

Chauhan, N.P., Vyas, J.R., Upadhyay, U.M.

Author's Affiliation

Abstract

The objective of the present research study is to formulate and evaluate extended tablets containing Diltiazem HCl to have better patient compliance and reduce side effects. The extended release tablets of Diltiazem HCl was prepared by direct Compression method using polymers like HPMC K4M, HPMC K15M, HPMC K100M, Glyceryl behanate, Glyceryl palmitostearate and Ethyl Cellulose in different concentrations. Formulated tablets were characterized for different parameters like hardness, thickness, weight variation, Friability, Disintegration time, % Cumulative drug release etc. A 3² factorial design was employed to study the effect of Glyceryl Dibehanate & Glyceryl Palmosterate in tablets. From the formulated factorial batches, F6 batch containing 15% Glyceryl Dibehanate and 15% Glyceryl Palmosterate   showed the % CDR of 94.43 %. The tablets of Diltiazem HCl was formulated to give extended release effect using various polymers. From the results obtained, it was found that concentration of polymer played important role in achieving desired % CDR of the formulated tablets. Hence the optimum concentration of Glyceryl behanate & Glyceryl palmitostearate were required to formulate extended release tablets. The application of experimental design was helpful in obtaining optimum formulation with less number of experiments. From the results obtained, it was concluded that the optimized formulation containing Glyceryl Dibehanate and Glyceryl Palmosterate shows better release with extended drug release properties. Hence Glyceryl Dibehanate is a potential polymer for formulation of extended release tablets.

Keywords

Extended release tablets, Diltiazem HCl, Hypertension

Cite This Article

Chauhan, N.P., Vyas, J.R., Upadhyay, U.M. (2015). Formulation and Evaluation of Extended Release Tablets of Diltiazem HCl, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 69-79.