Formulation Development and Evaluation of Novel Bioadhesive Vaginal Gel

Author(s)

Thombre, N.A., Pawar, P.D., Patil, S.A., Pawar, S.S., Kshirsagar, S.J.

Author's Affiliation

Abstract

The aim of this formulation was to achieve better patient compliance by increasing residence time and thus increase in bioavailability. Due to the wide significance such as large surface area rich blood supply, avoidance of first pass metabolism. Ciclopirox Olamine (CPO) is an antifungal, antibiotic, anti-inflammatory agent and is a class II drug. Various combinations of polymers and excipients were selected. CPO was dissolved in water followed by dispersing the polymers. Cellulose derivatives and natural polymer dispersions were prepared by overnight soaking to achieve complete hydration. The other water soluble ingredients were dissolved in water. These systems were combined and mixed properly to get homogeneous mixture. From the various combinations of polymer studied for this formulation, the HPMC K4M and carbopol 940 were showed good bioadhesive properties and thus longer residence time. So this combination was selected. The 99.06% drug release was obtained at the end of eight hour, and due to mucoadhesive polymers retention of the drug was increased. The mucoadhesive strength of the optimized formulation was found to be 0.52±0.01N which increased residence time of the formulation. Stable formulation was obtained containing lactobacilli without any growth. The spreadability and viscosity of the optimized batch were compared with the marketed formulation Candid-V gel and it was found that the spreadability of the optimized batch was better than that of the marketed formulation. The viscosity of the optimized batch was higher than that of the marketed one thus release was prolonged.

Keywords

Ciclopirox Olamine, Antifungal gel, HPMC K4M, Carbopol 940

Cite This Article

Thombre, N.A., Pawar, P.D., Patil, S.A., Pawar, S.S., Kshirsagar, S.J. (2015). Formulation Development and Evaluation of Novel Bioadhesive Vaginal Gel, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 161-168.