Topical drug delivery system was first came into discussion more than 40 years ago. Transdermal drug delivery has generated great thrill amongst most of the pharmaceutical companies since 1990s. Since then, the tradition of transdermal drug delivery system transferred into large scale industries. The transdermal route can be proved better to bypass the first pass effect and to avoid other side effects related to oral route and can act as a favorite route for systemic or local drug delivery. This can also be proved good for betterment of patients. Solid lipid nanoparticles (SLNs) have shown many permeability enhancing properties and therefore are newly introduced in research area for topical delivery of drugs. Solid lipid nanoparticles (SLNs) are very alluring drug carrier systems to be used for topical purposes because of their different required effects on skin aside from their skin accumulation or distribution raising characteristics. SLNs are attractive systems because of their solid matrix which may be helpful in preventing the explosive release generally seen in conventional delivery systems. SLNs via topical route provide various benefits such as enhanced skin permeation, improved drug delivery etc. This article reviews various aspects of SLNs including their mechanism of penetration, preparation, evaluation parameters, prospective advantages and their applications in topical drug delivery.
Solid Lipid Nanoparticles, Transdermal Drug Delivery System, Mechanism of penetration, Skin accumulation, First pass effect
Cite This Article
Tayal, P. (2015). Implication of Solid Lipid Nanoparticles for Topical Drug Delivery, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 301-316.