In-Vitro Anticancer Activity of Ethanolic Extract of Leaves of Aegle marmelos in HT 29 Human Colon Cancer Cell Lines

Author(s)

Pathakota, R., Chunduru, S., Damu, U.S., Pitta, L.

Author's Affiliation

Abstract

The present study was designed to evaluate the in-vitro cytotoxicity activity of ethanolic extract of leaves of Aegle marmelos in HT 29 human cancer cell lines. In this study the extract was tested using human cancer cell lines HT-29 for its effects on cell viability, growth inhibition and cell morphology. Cell viability, inhibition were determined by XTT-assay. Morphology was studied by using DAPI staining technique. The results showed decreased cell viability and increased growth inhibition in a concentration dependant manner and also altered the cell morphology after treatment with the plant extract. The data demonstrated that ethanolic extract of leaves of Aegle marmelos has a potential cytotoxicity activity on HT29 cell lines.

Keywords

Aegle marmelos, HT29 Human cell lines, anti cancer, XTT-assay, DAPI staining

Cite This Article

Pathakota, R., Chunduru, S., Damu, U. S., Pitta, L. (2017). In -Vitro Anticancer Activity of Ethanolic Extract of Leaves of Aegle marmelos in HT 29 Human Colon Cancer Cell Lines, International Journal for Pharmaceutical Research Scholars (IJPRS), 6(1), 104-108.