Preparation and Characterization of a Series of Narrative Pyrimidine Derivatives

Author(s)

Vakhariya, C., Ram, H., Shah, V.

Author's Affiliation

Abstract

Synthesis of a series of 1,2,3,4-tetrahydro-4-(substitutedphenyl)-6-methyl-2-oxo-N-(pyridin-3-yl)pyrimidine-5-carboxamide (4a-h) was achieved from different Aldehydes, N-(pyridin-3-yl)-3-oxo-butanamide and urea using catalytical amount of concentrated hydrochloric acid in ethanol the product obtained was isolated and recrystallized from ethanol. So to the fine yield. The structures of the products were supported by FTIR, ¹H NMR and mass spectral data.

Keywords

N-(Pyridin-3-yl)-3-Oxo-Butanamide, Aldehyde, Hydrochloric Acid, Urea Only Refluxed

Cite This Article

Vakhariya, C., Ram, H., & Shah, V. (2015). Preparation and Characterization of a Series of Narrative Pyrimidine Derivatives, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(4), 141-145.