Synthesis and Biological Activity of Some Novel Pyrimidine Derivatives

Author(s)

Ahmed, O., Begum, F., Fatima, N., Salahuddin, Md.

Author's Affiliation

Abstract

To synthesize and characterize novel pyrimidine derivatives and screen them for anti-inflammatory activity. A series of four 6, 7-dihydro-3-aceto substituted pentaleno [2, 1-d] pyrimidin-4-one derivatives (PM1-PM4) were synthesized from 2-amino-3, 4, 5, 6-tetra hydro pentalene-1-carboxamide. The synthesized compound, characterized on the basis of satisfactory analytical and spectral (H¹NMR, C¹³Mass and Elemental) data. Studies were carried out for the synthesized compounds which were also evaluated for anti-inflammatory activity by Carrageenan induced rat paw edema method. Indomethacin is used as standard anti-inflammatory agents. The synthesized compounds showed good anti-inflammatory activity, compared to standard drugs. Two of the compounds PM1 and PM3 exhibited significant anti-inflammatory activity, as compared to standard drug Indomethacin. We report the successful synthesis of novel pyrimidine derivative, as well as their spectral characterization.

Keywords

Anti-Inflammatory Activity, Pyrimidine, Indomethacin

Cite This Article

Ahmed, O., Begum, F., Fatima, N., & Salahuddin, Md. (2014). Synthesis and Biological Activity of Some Novel Pyrimidine Derivatives, International Journal for Pharmaceutical Research Scholars (IJPRS), 3(4), 103-108.