Synthesis and Biological Evaluation of Novel Carbazole Derivatives

Author(s)

Hedapara, K. R., Kharadi, G. J.

Author's Affiliation

Abstract

The main objective of this study is to synthesize 2-(substituted phenyl)-3-[{4-(1-naphthyl)-1, 3-thiazol- Considering the biological and chemical relevance of Carbazole containing derivatives, we have devised a novel and efficient synthesis of carbazole derivatives. The series of carbazole derivatives were synthesized in high yield and quality through simple straight forward reaction of 4-(oxiran-2-ylmethoxy)-9H-carbazole with various nucleophiles like piperazine containing heterocyclic derivatives or quinoline derivatives without using any base. The synthesized compounds were confirmed by NMR (¹H,¹³C), IR, Mass spectroscopy, elemental analysis.  All the compounds were screened vitro antibacterial activities. The Compound 2a exhibited good inhibition towards antimicrobial activity compared to the other compounds.

Keywords

4-(oxiran-2-ylmethoxy)-9H-carbazole, Carbazole derivatives, Heterocyclic derivatives, Nucleophiles like piperazine

Cite This Article

Hedapara, K. R., & Kharadi, G. J. (2014). Synthesis and Biological Evaluation of Novel Carbazole Derivatives. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 52-57.