Formulation and Evaluation of Chitosan Nanoparticles Containing Glibenclamide

Author(s)

Patel, C. J., Patel, D. V.

Author's Affiliation

Abstract

The objective of the present study was to develop Glibenclamide loaded nanoparticles using Chitosan as release control polymer. Different concentrations of Chitosan and Sodium Tripolyphosphate (TPP) were tried. A 3² full factorial design was used for optimization. The prepared nanoparticles were evaluated for particle size, zeta potential, % yield, and association efficiency, CPR after 1 hr and CPR after 20 hr. results obtained were subjected to regression analysis to obtain mathematical model. Using the developed model a checkpoint cum optimized formulation was developed on bases of desired characteristics and evaluated. In-vivo anti-hyperglycemic activity of the checkpoint batch was studied. The results obtained were in correlation with the predicted results. The formulation containing 0.75% w/v Chitosan and 0.4% w/v TPP was selected as optimized formulation.

Keywords

Glibenclamide, Chitosan, Nanoparticle, Factorial Design, Optimization

Cite This Article

Patel, C. J., & Patel, D. V. (2014). Formulation and Evaluation of Chitosan Nanoparticles Containing Glibenclamide. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 58-68.