Now a day Diabetes mellitus is one of the most popular diseases in research field. Diabetes is metabolic disease which is also the cause of various lives threatening disease. Medical science is very much advanced now but still we have no medicine without insulin for procurement of this disease. The medicines which are mainly using against diabetes have more side effect than that of efficiency. That’s why we are going for natural or traditional medicine. Tinospora cordifolia has significant anti-diabetic activity in diabetic animals and has an efficacy of 50% to 58% compared to insulin. The alkaloid rich fraction of tinospora including palmatine has been reported for insulin-mimicking activity which ultimately helps to release insulin from corresponding cell in vitro and in vivo. Different animal model study has been done for reviewing the antidiabetic activity of Tinospora plant. In a study diabetes is induced by injecting alloxan monohydrate (180 mg/kg bw) intraperitoneally and Tinospora cordifolia extract (20ml/kg bw) was administrated orally twice a day. The whole plant extract of Tinospora very significantly (p˂0.001) reduces the blood glucose level. In another study rats were injected with streptozotocin of 55 mg/kg b.w. intravenously to make them diabetic and the extract of tinospora was administered in different concentration. The extract of Tinospora cordifolia has significant (P < 0.05) anti-diabetic activity in diabetic animals and has an efficacy of 40% to 80% compared to insulin. In another study it has been found that the extract inhibits alpha glucosidase which ultimately show anti-diabetic properties. Tinospora cordifolia has various other biological activities but we have been focused on its anti-diabetic activity. The future prospect is to elucidate the structure of the chemical constituents which are mainly responsible for anti-diabetic activity. In future we may also modify the activity of those constituents by QSAR, pharmacophore study.
Diabetes Mellitus, Palmitine, Tinospora Cordifolia
Cite This Article
Chakraborty, D. (2016).Tinospora cordifolia and Its Anti-Diabetic Activity: A Review. International Journal for Pharmaceutical Research Scholars (IJPRS), 5(4), 38-47.