Anticonvulsant Activity of Methanolic Extract of Jatamansi Churna

Author(s)

Kotresh, Y., Ramana, M. V., Madhulatha, B., Ravikumar, M.

Author's Affiliation

Abstract

Jatamansi churna was extracted with methanol and concentrated to obtain residue. The methanolic extract (MEJ) at a dose of 500mg/kg b.w, 250 mg/kg b.w by i.p route were tested for their anticonvulsant property against Maximum Electric Shock (MES) Induced Convulsion model in Swiss albino mice of either sex weighing between 18gms-22gms. A significant (p<0.01) anticonvulsant activity had been observed in the MEJ (500mg/kg b.w) followed by 250 mg/kg b.w. when compared to control group. Phytochemical screening reveals the presence of alkaloids, cardiac glycosides, flavonoids, steroids, tannins, triterpenoids, carbohydrates, proteins and saponins in the methanolic extract of jatamansi churna.

Keywords

Jatamansi Churna, MEJ, Anticonvulsant, Maximum Electric Shock

Cite This Article

Kotresh, Y., Ramana, M. V., Madhulatha, B., & Ravikumar, M. (2015). Anticonvulsant Activity of Methanolic Extract of Jatamansi Churna, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(4), 129-134.